Paracrine signaling in islet function and survival
نویسندگان
چکیده
منابع مشابه
c-Kit Receptor Signaling Regulates Islet Vasculature, β-Cell Survival, and Function In Vivo.
The receptor tyrosine kinase c-Kit plays an integral role in maintaining β-cell mass and function. Although c-Kit receptor signaling promotes angiogenesis in multiple cell types, its role in islet vasculature is unknown. This study examines the effects of c-Kit-mediated vascular endothelial growth factor isoform A (VEGF-A) and islet vascularization on β-cell function and survival using in vitro...
متن کاملc-Kit Receptor Signaling Regulates Islet Vasculature, b-Cell Survival, and Function In Vivo
The receptor tyrosine kinase c-Kit plays an integral role in maintaining b-cell mass and function. Although c-Kit receptor signaling promotes angiogenesis in multiple cell types, its role in islet vasculature is unknown. This study examines the effects of c-Kit–mediated vascular endothelial growth factor isoform A (VEGF-A) and islet vascularization on b-cell function and survival using in vitro...
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OBJECTIVE Somatostatin (SST) is secreted by islet delta-cells and by extraislet neuroendocrine cells. SST receptors have been identified on alpha- and beta-cells, and exogenous SST inhibits insulin and glucagon secretion, consistent with a role for SST in regulating alpha- and beta-cell function. However, the specific intraislet function of delta-cell SST remains uncertain. We have used Sst(-/-...
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Islet transplantation is the most valid approach to the treatment of type 1 diabetes. However, the function of transplanted islets is often compromised since a large number of β cells undergo apoptosis induced by stress and the immune rejection response elicited by the recipient after transplantation. Conventional treatment for islet transplantation is to administer immunosuppressive drugs to t...
متن کاملCollagen matrix support of pancreatic islet survival and function.
Diabetes mellitus is a chronic condition resulting from insufficient β-cell mass, which leads to improper glycemia regulation. Research efforts have focused on expanding islets and β-cells in vitro for use in cell-based therapies to cure diabetes. Collagens are triple-helix extracellular matrix proteins with widespread expression in mammals. With multiple functions, collagen can provide structu...
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ژورنال
عنوان ژورنال: Journal of Molecular Medicine
سال: 2020
ISSN: 0946-2716,1432-1440
DOI: 10.1007/s00109-020-01887-x